General description

A cell-permeable tertabromobenzimidazolo TBB (Cat. Nos. 218699 and 218708) analog that acts as a highly selective (IC₅₀ >10 µM against 71 other kinases) ATP-competitive inhibitor against CK2 (IC₅₀ = 500 nM; K_i = 250 nM) and ERK8 (IC₅₀ = 500 nM). K66 is reported to be more selective than either TBB or DMAT and selective CK2 inhibition by K66 is shown to be cytotoxic to non-ERK8-expressing Jurkat cells.

A cell-permeable tertabromobenzimidazolo TBB (Cat. Nos. 218699 and 218708) analog that acts as a highly selective (IC₅₀ >10 µM against 71 other kinases) ATP-competitive inhibitor against CK2 (IC₅₀ = 500 nM; K_i = 250 nM) and ERK8 (IC₅₀ = 500 nM). K66 is reported to be more selective than either TBB or DMAT and selective CK2 inhibition by K66 is shown to be cytotoxic to non-ERK8-expressing Jurkat cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Pagano, M.A., et al. 2008. Biochem. J.415, 353.

Packaging

Packaged under inert gas

10 mg in Glass bottle

Warning

Toxicity: Irritant (B)